• Study Aims to Resolve Variants of Uncertain Significance

    Oct 03 | Clinical Research News | A pioneering study led by Dr. Lachlan Jolly at the University of Adelaide’s Neurobiology Research Group is transforming genetic diagnostics by resolving variants of uncertain significance (VUS) using skin samples. Many patients with VUS lack a definitive diagnosis because RNA from disease-causing genes often can't be extracted from accessible tissues like blood or skin. More

  • Scope of Things: Trial Planning Skews Conclusions, AI Diversity Help, News of the Month

    Oct 02 | Clinical Research News | In this month’s episode of the Scope of Things, host Deborah Borfitz covers everything you need to know about a pending launch of a large treatment trial for Graves’ disease, a recruitment campaign for a diagnostic tampon, Walgreens and BARDA’s new partnership, how eligibility criteria has been excluding people of African or Middle Eastern descent from cancer studies, and more. More

  • Follow the Money: GPCR Targets, Upacicalcet, AAV-Delivered Cancer Immunotherapy, More

    Sep 26 | Clinical Research News | Superluminal Medicines is focusing on supporting the progression of their lead program into clinical development and increase the number of small molecule drug discovery programs focused on high-value G protein-coupled receptor (GPCR) targets; Pathalys Pharma wraps up upacicalcet clinical trials; Vironexis anticipates initiating patient enrollment of a Phase 1/2 trial of VNX-101 in the fourth quarter of 2024, which will mark the first-ever clinical trial of an AAV-delivered cancer immunotherapy; and more. More

  • AstraZeneca, Moffitt Cancer Center Partner, Firefly Neuroscience Advances AI Tech, More

    Sep 25 | Clinical Research News | Moffitt Cancer Center announced a strategic collaboration with AstraZeneca that aims to accelerate the development of cell therapies, specifically chimeric antigen receptor T cell and T cell receptor therapies; Firefly Neuroscience announced the advancement of its artificial intelligence-powered Brain Network Analytics (BNA) technology; and more. More

  • PCORI Offers $100 Million For Youth Research, Children’s Health Promotion

    Sep 24 | Clinical Research News | PCORI announced earlier this month that they are inviting proposals through eight new funding opportunities. These include three PCORI Funding Announcements for patient-centered comparative clinical effectiveness research (CER). Letters of intent are due October 1, 2024, and applications will be accepted until January 14, 2025. More

  • Flatiron Health Expands its Mission to Make Trials More ‘Pragmatic’

    Sep 19 | Clinical Research News | The patient groups more likely to be treated at community practices with limited or no access to oncology clinical trials are the same groups historically underrepresented in such trials, finds a nationwide study conducted by Flatiron Health. The reasons for this are unknown, but the research effectively rules out quality of care and location of the practices. More

  • Trial Emulation Study Taps Real-World Data to Help Fill Evidence Gaps

    Sep 17 | Clinical Research News | Researchers in the UK recently emulated a large, randomized controlled trial (RCT) testing the effectiveness of two blood thinners using data from real-world patients to help understand whether the real-world data can be used to explore treatment effects in people underrepresented in the study. While results of the reference trial and its simulation didn’t entirely align, the approach could help fill the evidence gap for population groups largely missing in RCTs. More

  • New Treatment Option for Graves’ Disease Finally ‘On the Horizon’

    Sep 12 | Clinical Research News | Later this year, Immunovant will be launching a late-stage clinical trial for Graves’ disease—the first in a very, very long time. The preferred treatment option currently is methimazole, approved for medical use in the U.S. in 1950, but some patients require high doses of the drug to control their hyperthyroidism, and in up to half of cases long-term remission isn’t achievable short of surgery to remove the thyroid gland or radioactive iodine to destroy the thyroid and stop it from producing hormones. More

  • Closing the Gender Diagnostic Gap With a Sample-Collecting Tampon

    Sep 10 | Clinical Research News | Women’s health startup Daye is on a mission to bridge the gender diagnostic gap with a tampon for the self-collection of vaginal and cervical fluids analyzed for biomarkers of sexually transmitted infections (STIs), including human papillomavirus (HPV). The tampon is a familiar device used by over 90% of the female population and much better suited to their anatomy than conventional vaginal swabs. More

  • uMotif Buys ClinOne

    Sep 09 | Clinical Research News | uMotif has acquired site platform provider ClinOne. The acquisition is the logical next step in a successful two-year strategic partnership between the companies to leverage a single, integrated solution for electronic clinical outcomes assessments (eCOA) and electronic informed consent (eConsent) technology. Financial details were not released. More
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SOT

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News Senior writer Deborah Borfitz welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.

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