Press Releases
Creative Biogene Generates Professional Cell Expression System to Accelerate Bioproduction Stable Cell Line Development
May 17, 2022, 15:36 PM
by
Creative Biogene, the leading global client service and solutions provider focuses on developing high-quality products and cutting-edge technologies to support scientific research including basic life sciences research, biomedical research and preclinical drug discovery etc. With the support of an experienced team custom-service-centered business model, Creative Biogene recently announced the release of its professional expression system to accelerate bioproduction stable cell line development.
Overexpression of proteins is critical for many applications, including studying the function of genes, as well as functional assays and screening. Mammalian cells in post-translational modification and protein folding. However, protein overexpression requires extensive cell culture experience and expertise, Creative Biogene provides services for the generation of stable cell lines that can overexpress virtually any protein of interest in the cell line of the customer's choice.
Creative Biogene has the ability to support the construction of gene cell expression lines, construct the customer's gene of interest into a suitable mammalian expression vector or lentiviral vector, and then generate high titer lentivirus. The best strategy and corresponding carrier system can also be selected according to customer requirements. In addition, Creative Biogene offers stable cell clone selection, transfection or transduction of target cells to select stable cell clones. Gene expression in stable cell clones at Creative Biogene is assessed by one or more assays, such as Western blotting, ELISA, real-time PCR, or reporter gene assays, among others.
Creative Biogene provides comprehensive services for the generation of stable cell lines for bioproduction, covering all steps of stable cell line generation, from first gene synthesis to final delivery of high-yielding cell clones. In order to improve the yield and selection efficiency of recombinant proteins, Creative Biogene has combined genome editing platforms to develop mammalian cell expression systems, including glutamine synthase (GS)-based selection of cells and dihydrofolate reductase (DHFR)-based selection Cell. These cells have been optimized using Creative Biogene's gene-editing technology and have been adapted for high-density suspension culture. Compared with traditional expression systems, the use of these engineered mammalian cells can significantly improve the success rate of obtaining high-yielding cell clones and shorten the time of overall process development.
Creative Biogene has extensive experience in generating stable cell lines for bioproduction, including 100% accurate gene synthesis, robust vector design and construction, efficient gene delivery, rapid screening of positive clones, rigorous Q&C systems etc.
“Based on years of experience in cell line development, we focus on optimizing all parameters of your cell line to efficiently produce stable cell lines according to your requirements.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “Creative Biogene is committed to building a business model centered on customized services, and is committed to optimizing the drug development process, leveraging available resources, and building teams with diverse backgrounds for future drug discovery.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.
Overexpression of proteins is critical for many applications, including studying the function of genes, as well as functional assays and screening. Mammalian cells in post-translational modification and protein folding. However, protein overexpression requires extensive cell culture experience and expertise, Creative Biogene provides services for the generation of stable cell lines that can overexpress virtually any protein of interest in the cell line of the customer's choice.
Creative Biogene has the ability to support the construction of gene cell expression lines, construct the customer's gene of interest into a suitable mammalian expression vector or lentiviral vector, and then generate high titer lentivirus. The best strategy and corresponding carrier system can also be selected according to customer requirements. In addition, Creative Biogene offers stable cell clone selection, transfection or transduction of target cells to select stable cell clones. Gene expression in stable cell clones at Creative Biogene is assessed by one or more assays, such as Western blotting, ELISA, real-time PCR, or reporter gene assays, among others.
Creative Biogene provides comprehensive services for the generation of stable cell lines for bioproduction, covering all steps of stable cell line generation, from first gene synthesis to final delivery of high-yielding cell clones. In order to improve the yield and selection efficiency of recombinant proteins, Creative Biogene has combined genome editing platforms to develop mammalian cell expression systems, including glutamine synthase (GS)-based selection of cells and dihydrofolate reductase (DHFR)-based selection Cell. These cells have been optimized using Creative Biogene's gene-editing technology and have been adapted for high-density suspension culture. Compared with traditional expression systems, the use of these engineered mammalian cells can significantly improve the success rate of obtaining high-yielding cell clones and shorten the time of overall process development.
Creative Biogene has extensive experience in generating stable cell lines for bioproduction, including 100% accurate gene synthesis, robust vector design and construction, efficient gene delivery, rapid screening of positive clones, rigorous Q&C systems etc.
“Based on years of experience in cell line development, we focus on optimizing all parameters of your cell line to efficiently produce stable cell lines according to your requirements.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “Creative Biogene is committed to building a business model centered on customized services, and is committed to optimizing the drug development process, leveraging available resources, and building teams with diverse backgrounds for future drug discovery.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.
