Press Releases

For solid dosage formulation chemists, it is usually a formidable task to crystalize the moisture adsorption conditions for pharmaceutical substances. To help researchers better solve this problem, CD Formulation avails its position in the industry as a contract service provider and announces to offer hygroscopicity evaluation for custom pharmaceutical formulation projects.

Hygroscopicity is a terminology commonly used for describing the interaction of a material with water. Matter-of-factly, both active pharmaceutical ingredients (APIs) and excipients in solid dosage forms will absorb water vapor from manufacture and subsequent storage stages. As excessive amounts of water will adversely affect the physical and chemical stability of the API and the functionality of the excipients, determining hygroscopicity is therefore a very critical step, especially for drugs that degrade greatly in the presence of water.

“Usually, moisture absorption evaluations start from the early stages of drug development. One thing that needs to be noted is that the importance of characterization of the equilibrium moisture content (EMC) of the formulated material equals that of figuring out the rate at which this level is achieved,” says a senior scientist from CD Formulation.

Based on the hygroscopicity data of various formulations, drug developers can better select the most suitable solid form of the drug for further development. Several methods are most frequently used for pharmaceutical hygroscopicity evaluation, that is, gravimetric sorption analysis (GSA) method, thermogravimetric analysis (TA), radio-frequency-based method, halogen drying as well as many other techniques. Recent studies have found that high throughput method of hygroscopicity classification utilizing sorption analysis is more robust and can provide precise and reproducible data while less compound and time are required.

CD Formulation’s laboratories can test products of any scale, and comprehensive hygroscopicity evaluation for APIs can be performed according to different standards. Please visit https://www.formulationbio.com/hygroscopicity-evaluation.html to learn more details or email us directly at contact@formulationbio.com.

About CD Formulation

As a science-driven company, CD Formulation has accumulated rich experience in drug formulation and is qualified to serve the pharmaceutical industry by providing CRO services to develop, design and produce pharmaceutical excipients for solid, semi-solid and liquid dosage forms. With an innovative spirit and a down-to-earth attitude, the company is missioned to address the long-standing issue of new API development. It has successfully completed several development projects and proudly extends its capability, which covers generic to innovative formulation with an ambition to enhance the solubility and bioavailability of difficult-to-formulate compounds. Equipped with advanced facilities that comply with GMP regulations, the company continues to provide personalized solutions for clients, taking into consideration the unique requirements and circumstances of each new project, whether it is initial pre-formulation trials or commercial manufacturing.