Press Releases

As a CRO service provider for custom pharmaceutical formulation projects, CD Formulation announces today that it is able to conduct API-excipient compatibility analysis service for customers across the globe who have a drug development project.

“The testing and analysis of the API-excipient compatibility is a very critical step in the drug preformualtion stage. We know that a drug substance is usually more stable by itself than in a formulation with excipients. Inappropriate dosage forms can interact with drug substances and in worst cases can even cause drug degradation,” says the Marketing Chief of CD Formulation.

“With strong expertise and in-depth understanding of physical and chemical API-excipient interactions, our scientists can assist clients to select the most appropriate excipients in dosage form design. Our comprehensive services have many benefits, such as to make the drug being developed easy to administer, to promote drug release and bioavailability, and to extend its shelf life,” the spokesperson further explains.

Techniques used in the analysis of API-excipient compatibility include: thermal methods of analyses, spectroscopic technique, microscopic technique, and chromatography. And these techniques cover the following wide-ranged methods: differential scanning calorimetry (DSC), isothermal microcalorimetry, hot stage microscopy (HSM), vibrational spectroscopy, powder X-ray diffraction (PXRD), solid state nuclear magnetic resonance spectroscopy (ss NMR), scanning electron microscopy (SEM), self-interactive chromatography (SIC), thin layer chromatography (TLC), and high-performance liquid chromatography (HPLC).

With both expertise and advanced equipment, CD Formulation’s API-excipient compatibility analysis service can help assess the risk of excipient interactions prior to formulation development and also save both time and cost for clients.

In addition to API-excipient compatibility analysis, the company is also skilled in other customized preformulation services, such as crystallinity determination, amorphous content determination, hygroscopicity evaluation, particle size analysis, moisture content determination, solubility analysis, LogP/LogD/pKa analysis as well as stability analysis. For more relevant information, please visit: https://www.formulationbio.com/api-excipient-compatibility.html or email us directly at contact@formulationbio.com.

About CD Formulation

Considering the huge demand for greater flexibility and efficiency in drug formulation development, CD Formulation has launched a comprehensive range of custom services that cover nearly every aspect of pharmaceutical preparation. Scientists at CD Formulation can provide more intelligent approach to excipient design and thus solve the long-standing issue of poor bio-solubility and bioavailability for newer APIs. With years of accumulation, the company now works closely with the pharmaceutical industry as a contract service organization, offering outstanding expertise to handle complex pharmaceutical formulation.